Global ADME-Toxicology Testing Market Growth, Share, Size, Trends and Forecast (2025 - 2031)

• February 2020, With the exception of the Swedish market, Thermo Fisher ScientificTM will have the exclusive right to offer ASTar to the market in all geographies. In terms of fast AST testing, the partnership is exclusive to both companies. The two companies will collaborate closely to offer customers a comprehensive AST portfolio.
• January 2020, Thermo Fisher Scientific has introduced a next-generation, compressor-free plate sealer that is designed to reduce operator maintenance while providing unparalleled process customization capabilities, intuitive operation, and significant work efficiencies. Biotechnology, pharmaceutical, and academic research laboratories can now benefit from a system that simplifies plate sealing while improving reliability and productivity for both stand-alone and integrated robotic projects.

The Global ADME-Toxicology Testing Market is segmented by Technology into Cell Culture, High Throughput, Molecular Imaging, and OMICS Technology, each offering distinct advantages in evaluating drug safety and efficacy. The Cell Culture technology remains a cornerstone of toxicology testing, providing a controlled environment to observe the effects of drugs on cellular structures and functions. This method is widely used in early-stage drug testing to predict cytotoxicity and other cellular responses. The High Throughput technology, on the other hand, allows for the rapid screening of a large number of compounds, making it particularly useful in early drug discovery. With the increasing need for faster and more efficient testing, high throughput screening is gaining popularity across pharmaceutical companies. Molecular Imaging technology enables the visualization of biological processes in real-time, providing valuable insights into drug absorption, distribution, metabolism, and excretion (ADME) at the molecular level. OMICS Technology (including genomics, proteomics, and metabolomics) is being increasingly used to identify biomarkers and gain a deeper understanding of drug-induced toxicity at the molecular and cellular levels, supporting personalized medicine approaches.

The Method segmentation of the ADME-Toxicology Testing Market includes Cellular Assay, Biochemical Assay, In-Silico, and Ex-Vivo testing methods, which serve different functions in drug safety evaluation. Cellular Assay methods are vital for assessing the cytotoxic effects of drug candidates on specific cell types, offering insights into cellular responses such as apoptosis, necrosis, or proliferation. The Biochemical Assay segment is focused on measuring the interaction between drug candidates and specific biomolecules like enzymes, proteins, or receptors, aiding in understanding the underlying mechanisms of drug toxicity. In-Silico methods, using computational models, are becoming increasingly important as they help predict the toxicological profiles of drugs before clinical testing, reducing time and cost in the drug development process. Finally, Ex-Vivo testing involves studying drug effects on human or animal tissue outside the body, which offers more realistic insights into how drugs interact with complex biological systems compared to traditional in-vitro assays.

In terms of Application, the ADME-Toxicology Testing Market is segmented into Systemic Toxicity, Renal Toxicity, Hepatotoxicity, Neurotoxicity, and Others, reflecting the broad range of toxicological effects drugs can have on the body. Systemic Toxicity testing assesses the overall toxic effects a compound may have on the entire body, often involving multiple organ systems. Renal Toxicity and Hepatotoxicity are critical areas, as kidney and liver damage are common side effects of many drugs, making these tests essential for ensuring drug safety. Neurotoxicity testing is increasingly important as the pharmaceutical industry develops more drugs targeting the nervous system, requiring comprehensive safety assessments to avoid harmful effects on the brain and nerves. The Others category encompasses a range of other toxicological concerns, including reproductive toxicity, immunotoxicity, and cardiotoxicity, highlighting the diverse and evolving needs for ADME-toxicology testing across different therapeutic areas. These applications are crucial in ensuring the safety and efficacy of new drugs before they reach the market, and as regulatory standards become more stringent, the demand for advanced ADME-toxicology testing solutions continues to grow.

Global ADME-Toxicology Testing Segment Analysis

In this report, the Global ADME-Toxicology Testing Market has been segmented by Technology, Method, Application, and Geography.

Global ADME-Toxicology Testing Market, Segmentation by Technology

The Global ADME-Toxicology Testing Market has been segmented by Technology into Cell Culture, High Throughput, Molecular Imaging and OMICS Technology.

The global ADME-Toxicology Testing market is segmented by technology to analyze the effectiveness of different testing methods. Here's a breakdown of the key technology segments:

This widely adopted technology uses simulated cellular environments to assess a drug candidate's absorption, metabolism, and potential toxicity. It offers near-natural conditions and accurate results at a cellular level.

This technology automates testing procedures, allowing for rapid evaluation of a large number of drug candidates simultaneously. This is particularly useful in the early stages of drug discovery to identify promising leads efficiently.

This segment includes Omics technologies (genomics, proteomics) and molecular imaging. These advanced techniques provide deeper insights into drug interactions and potential toxicity mechanisms, aiding in the development of safer and more effective drugs.

Understanding the strengths and limitations of each technology helps researchers choose the most appropriate method for their specific needs, ultimately contributing to a more efficient and successful drug discovery process.

Global ADME-Toxicology Testing Market, Segmentation by Method

The Global ADME-Toxicology Testing Market has been segmented by Method into Cellular Assay, Biochemical Assay, In-Silica, and Ex-vivo.

The Global ADME-Toxicology Testing Market is segmented by Method into Cellular Assay, Biochemical Assay, In-Silico, and Ex-Vivo, each catering to different testing requirements in the field of drug development and safety testing. The Cellular Assay segment plays a crucial role in assessing the impact of drug candidates at the cellular level, providing vital insights into drug toxicity, efficacy, and cellular behavior. These assays are widely used to evaluate the potential of new drugs, as they can detect various cellular responses, such as cytotoxicity, proliferation, and apoptosis. The increasing demand for more accurate and reliable testing methods in pharmaceutical and biotechnology industries is driving the growth of the cellular assay market, as these assays help reduce the reliance on animal models and improve drug development efficiency.

The Biochemical Assay segment focuses on testing the effects of drugs on specific biochemical pathways or proteins within a system. These assays are essential for understanding the interaction between drug molecules and target proteins, enzymes, or receptors, providing insights into their mechanisms of action and potential toxicity. Biochemical assays are particularly valuable in the early stages of drug development, enabling researchers to evaluate drug candidates before advancing to more complex in-vivo testing. As the pharmaceutical industry continues to focus on precision medicine and targeted therapies, the demand for biochemical assays is expected to increase, especially for the development of novel therapeutics.

The In-Silico segment refers to computer-based modeling and simulations used to predict the absorption, distribution, metabolism, and excretion (ADME) properties of drug compounds, as well as their potential toxicological effects. In-silico methods are increasingly being utilized to complement traditional testing approaches due to their cost-effectiveness and ability to process large amounts of data quickly. These methods are gaining traction in drug discovery and development, as they can simulate various biological processes and predict the toxicity profiles of new drug candidates. The Ex-Vivo segment, on the other hand, involves testing drugs on human or animal tissue outside of the living organism, offering a more realistic environment than traditional cell-based assays. Ex-vivo testing is valuable for assessing the effects of drugs on complex tissue structures, allowing for more accurate predictions of their potential effects in vivo. As pharmaceutical companies continue to focus on reducing costs and improving the accuracy of drug testing, both the in-silico and ex-vivo segments are expected to see continued growth in the ADME-toxicology testing market.

Global ADME-Toxicology Testing Market, Segmentation by Application

The Global ADME-Toxicology Testing Market has been segmented by Application into Systemic Toxicity, Renal Toxicity, Hepatotoxicity, Neurotoxicity and Others.

The global ADME-Toxicology Testing market caters to various applications in drug discovery and development. Here's a breakdown of the key segments:

This application segment focuses on identifying potential toxicities of drugs throughout the body. It includes testing for systemic toxicity (overall effects), organ-specific toxicities like hepatotoxicity (liver damage) and nephrotoxicity (kidney damage), and neurotoxicity (nervous system effects).

ADME-Tox testing plays a crucial role in optimizing drug design. It helps assess factors like absorption, distribution, metabolism, and excretion of potential drugs, allowing researchers to refine formulations for better efficacy and safety.

Regulatory Compliance: Regulatory bodies mandate thorough ADME-Tox testing to ensure drug safety before clinical trials and market approval. This application segment is driven by the need to meet stringent regulatory requirements across the globe.

This segmentation ensures that ADME-Tox testing services address various aspects of drug development, ultimately contributing to safer and more effective medications.

Global ADME-Toxicology Testing Market, Segmentation by Geography

In this report, the Global ADME-Toxicology Testing Market has been segmented by Geography into five regions; North America, Europe, Asia Pacific, Middle East and Africa and Latin America.

Global ADME-Toxicology Testing Market Share (%), by Geographical Region, 2024

The global ADME-Toxicology testing market is currently estimated to be around $2.2 billion, and is poised for significant growth in the coming years. This market focuses on in vitro (laboratory-based) testing methods to assess a drug candidate's Absorption, Distribution, Metabolism, and Excretion (ADME) properties, alongside its potential for toxicological effects. This information is crucial in the early stages of drug discovery, helping researchers identify promising compounds and avoid those with poor absorption or dangerous side effects.

In terms of market growth, analysts predict a Compound Annual Growth Rate (CAGR) of around 9.8% until 2030. This growth is attributed to several factors, including the rising demand for faster and more efficient drug development processes. Additionally, increasing regulations around drug safety and the growing importance of ethical considerations in research are driving the adoption of in vitro ADME-Tox testing methods as a more humane alternative to traditional animal testing.

This market is expected to benefit from advancements in technology like microfluidics and automation, which can improve the accuracy, efficiency, and affordability of ADME-Tox testing. Furthermore, the growing focus on personalized medicine and targeted therapies is likely to create new opportunities for specialized ADME-Tox testing services. Overall, the ADME-Toxicology testing market is well-positioned for continued expansion due to its critical role in streamlining drug discovery and ensuring patient safety.